| 赵玉芹,刘耀庭,高月敏,田遂,吕学海.迷走神经磁刺激对脑桥梗死后吞咽障碍患者吞咽功能的影响[J].中国康复,2026,41(6):353-357 |
| 迷走神经磁刺激对脑桥梗死后吞咽障碍患者吞咽功能的影响 |
| The impacts of vagus nerve stimulation on swallowing function and serum growth differentiation factor-15, C-reactive protein, and Visinin like protein-1 in patients with swallowing disorders after pontine infarction |
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| DOI：10.3870/zgkf.2026.06.006 |
| 中文关键词: 脑桥梗死 吞咽障碍 迷走神经磁刺激 吞咽功能 GDF-15 CRP VILIP-1 |
| 英文关键词: pontine infarction swallowing disorders vagus nerve stimulation swallowing function GDF-15 CRP VILIP-1 |
| 基金项目:邯郸市科学技术研究与发展计划（24422083035ZC） |
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| 中文摘要: |
| 目的：探究迷走神经磁刺激（VNS）对脑桥梗死后吞咽障碍患者吞咽功能及血清生长分化因子-15（GDF-15）、C反应蛋白（CRP）、视锥蛋白样蛋白1（VILIP-1）水平的影响。方法：将2024年6月至2025年6月本院收治的脑桥梗死后吞咽障碍患者80例通过随机数字表法分为2组各40例，2组均进行常规吞咽康复训练，电刺激组在此基础上采用神经肌肉电刺激（NMES）治疗，磁刺激组在此基础上采用迷走神经磁刺激（VNS）治疗，比较2组治疗前后吞咽功能、血清学指标、表面肌电图和生活质量。结果：2组治疗后标准吞咽功能评定量表（SSA）得分及GDF-15、CRP、VILIP-1、吞咽时长均较治疗前降低（均P＜0.01），且磁刺激组各项指标均明显低于电刺激组（P＜0.01）；2组治疗后最大波幅值及吞咽生命质量量表（SWAL-QOL）评分均较治疗前升高（均P＜0.01），且磁刺激组各项指标均明显高于电刺激组（P＜0.01，0.05）。结论：VNS能够有效改善脑桥梗死后吞咽障碍患者的吞咽功能，降低GDF-15、CRP、VILIP-1水平，增强咽喉表面肌肉功能，提高患者生活质量水平。 |
| 英文摘要: |
| Objective: To explore the impacts of vagus nerve stimulation (VNS) on swallowing function and serum growth differentiation factor-15 (GDF-15), C-reactive protein (CRP), and Visinin like protein-1 (VILIP-1) in patients with swallowing disorders after pontine infarction. Methods: From June 2024 to June 2025, 80 patients with swallowing disorders after pontine infarction in our hospital were randomly assigned into an electrical stimulation group ［using neuromuscular electrical stimulation (NMES) on the basis of routine swallowing rehabilitation training, 40 cases］ and a magnetic stimulation group (using VNS on top of routine swallowing rehabilitation training, 40 cases). The swallowing function, serological indicators, surface electromyography, and quality of life were compared. Results: After therapy, the scores of the standard swallowing function assessment scale (SSA) decreased in both groups, and the score of the magnetic stimulation group was prominently lower (P<0.01). After therapy, GDF-15, CRP, and VILIP-1 all decreased in both groups, and the indicators were prominently lower in the magnetic stimulation group (P<0.01). After therapy, both groups showed an increase in maximum wave amplitude and a decrease in swallowing duration, with the magnetic stimulation group showing more prominent changes (P<0.01). After therapy, the swallowing-quality of life scale (SWAL-QOL) increased in both groups, and the magnetic stimulation group scored prominently higher (P<0.01, 0.05). Conclusion: VNS can effectively improve the swallowing function of patients with swallowing disorders after pontine infarction, reduce GDF-15, CRP, and VILIP-1, enhance pharyngeal surface muscle function, and improve quality of life. |
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