| 张丽丽,王肃馨,王立峰,王辉.经皮耳迷走神经电刺激治疗脑卒中后疲劳的疗效观察[J].中国康复,2026,41(7):395-399 |
| 经皮耳迷走神经电刺激治疗脑卒中后疲劳的疗效观察 |
| Efficacy of transcutaneous auricular vagus nerve stimulation in the treatment of post-stroke fatigue |
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| DOI：10.3870/zgkf.2026.07.002 |
| 中文关键词: 经皮耳迷走神经电刺激 脑卒中后疲劳 临床疗效 |
| 英文关键词: transcutaneous auricular vagus nerve stimulation post-stroke fatigue clinical efficacy |
| 基金项目:陕西省重点研发计划项目（2024SF-YBXM-686）；西安市创新能力支撑计划-医学研究项目（23YXYJ0139） |
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| 中文摘要: |
| 目的：探讨经皮耳迷走神经电刺激治疗脑卒中后疲劳的疗效。方法：收集脑卒中后疲劳患者60例，随机分为研究组和对照组各30例，2组均予以基础治疗，在此基础上，研究组采用经皮耳迷走神经电刺激治疗，对照组采用经皮耳迷走神经假刺激治疗，均为20min/次，2次/日，连续治疗4周。治疗前后，分别采用疲劳严重程度量表（FSS） 、匹兹堡睡眠指数（PSQI） 、卒中生活质量量表（SS-QOL）、改良Barthel指数（MBI）对2组患者进行评估，并检测2组患者血清白介素-1β（IL-1β）、白介素-6（IL-6）水平。结果：治疗后，2组患者FSS、PSQI评分低于治疗前，且研究组低于对照组（P＜0.01）；2组患者SS-QOL、MBI评分高于治疗前（P＜0.01），且研究组高于对照组（P＜0.01）；2组患者血清IL-1β、IL-6水平低于治疗前，且研究组低于对照组（P＜0.01）；研究组患者FSS评分与血清IL-1β、IL-6水平呈正相关（P＜0.01）。结论：经皮耳迷走神经电刺激，能有效缓解脑卒中后疲劳患者疲劳程度，改善睡眠及生活质量，其变化与血清IL-1β、IL-6水平有关。 |
| 英文摘要: |
| Objective: To investigate the efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) in the treatment of post-stroke fatigue. Methods: A total of 60 patients with post-stroke fatigue were enrolled and randomly assigned to either an experimental group or a control group, with 30 patients in each group. Both groups received basic treatment. The experimental group was treated with taVNS, while the control group received sham taVNS. The treatment was administered twice daily for 20 min each session, over a continuous period of 4 weeks. The fatigue severity scale (FSS), Pittsburgh sleep quality index (PSQI), stroke-specific quality of life scale (SS-QOL), and modified Barthel index (MBI) scores were observed before and after treatment in both groups. Additionally, serum levels of interleukin-1β (IL-1β) and IL-6 were measured. Results: After treatment, FSS and PSQI scores decreased in both groups compared to pre-treatment levels, with the experimental group showing significantly lower scores than the control group (P<0.05). SS-QOL and MBI scores increased in both groups compared to pre-treatment levels, with the experimental group demonstrating significantly higher scores than the control group (P<0.01). Serum levels of IL-1β and IL-6 decreased in both groups after treatment compared to pre-treatment levels, with the experimental group exhibiting significantly lower levels than the control group (P<0.01). In the experimental group, FSS scores were positively correlated with serum IL-1β and IL-6 levels (P<0.01). Conclusion: TaVNS can effectively alleviate fatigue, improve sleep quality, and enhance the quality of life in patients with post-stroke fatigue. The mechanism may be associated with the downregulation of serum IL-1β and IL-6 levels. |
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