| 孙秀芬,李坤,孙亚鲁.腹部电刺激联合气道廓清技术对慢性阻塞性肺疾病患者肺功能及炎症指标的影响[J].中国康复,2026,41(7):409-413 |
| 腹部电刺激联合气道廓清技术对慢性阻塞性肺疾病患者肺功能及炎症指标的影响 |
| Effect of abdominal electrical stimulation combined with airway clearance techniques on pulmonary function and inflammatory markers in patients with chronic obstructive pulmonary disease |
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| DOI：10.3870/zgkf.2026.07.005 |
| 中文关键词: 气道廓清技术 腹部电刺激 慢性阻塞性肺疾病 肺功能 |
| 英文关键词: airway clearance techniques abdominal electrical stimulation chronic obstructive pulmonary disease pulmonary function |
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| 中文摘要: |
| 目的：观察腹部电刺激联合气道廓清技术（ACT）对慢性阻塞性肺疾病患者肺功能及炎症指标的影响。方法：将符合纳入标准的52例慢性阻塞性肺疾病患者分为对照组和观察组，每组26例，2组各有1例患者脱落，最终2组均为25例。对照组在常规康复治疗的基础上给予ACT治疗，观察组在对照组的基础上给予腹部电刺激。分别于治疗前、治疗2周和治疗4周后对患者进行评估，采用用力肺活量(FVC)、第1秒用力呼气容积(FEV1)和呼气峰流速(PEF)评估患者的肺功能，检测血清白细胞介素6（IL-6）、C反应蛋白（CRP）和肿瘤坏死因子-α (TNF-α)评估患者的肺部炎症，采用6分钟步行试验(6MWT)评估运动耐力，以圣乔治呼吸问卷(SGRQ)评价生活质量。结果：治疗前，2组患者的肺功能指标、炎症指标、6MWT结果、SGRQ评分比较均无明显差异；治疗2周后，2组患者FVC、FEV1、PEF、6MWT结果均较治疗前增加（P＜0.05）；治疗4周后，2组患者上述指标均较治疗前及治疗2周后增加（P＜0.05），且观察组在治疗2周、4周后，上述指标均高于对照组（P＜0.05）。治疗2周后，2组患者血清IL-6、CRP、TNF-α水平、SGRQ评分均较治疗前降低（P＜0.05），治疗4周后，2组患者上述指标均较治疗前及治疗2周后降低（P＜0.05），且观察组在治疗2周、4周后，上述指标均低于对照组（P＜0.05）。结论：腹部电刺激联合ACT治疗能明显提高慢性阻塞性肺疾病患者的肺功能、减轻炎症、提高患者的运动耐力及生活质量。 |
| 英文摘要: |
| Objective: To investigate the effects of abdominal electrical stimulation combined with airway clearance techniques on pulmonary function and inflammatory markers in patients with chronic obstructive pulmonary disease (COPD). Methods: A total of 52 patients with COPD who met the inclusion criteria were divided into a control group and an observation group, with 26 patients in each group. One patient dropped out from each group, resulting in 25 patients per group. The control group received airway clearance techniques based on conventional rehabilitation therapy, while the observation group received additional abdominal electrical stimulation. Assessments were conducted before treatment, and 2 and 4 weeks after treatment. Pulmonary function was evaluated using forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), and peak expiratory flow (PEF). Serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-α) were measured to assess pulmonary inflammation. Exercise tolerance was evaluated using the 6-minute walk test (6MWT), and quality of life was assessed using the St. George’s Respiratory Questionnaire (SGRQ). Results: Before treatment, there were no significant differences between the two groups in pulmonary function indicators, inflammatory markers, 6MWT results and SGRQ scores. After 2 weeks of treatment, FVC, FEV1, PEF and 6MWT significantly increased in both groups compared with baseline (P<0.05). After 4 weeks of treatment, these indicators further increased in both groups compared with baseline and 2-week measurements (P<0.05). Moreover, the observation group showed significantly higher values in the above indicators than the control group at both 2 and 4 weeks after treatment (P<0.05). After 2 weeks of treatment, serum IL-6, CRP and TNF-α levels, as well as SGRQ scores, significantly decreased in both groups compared with baseline (P<0.05). After 4 weeks of treatment, these indicators further decreased in both groups compared with baseline and 2-week measurements (P<0.05), and the observation group exhibited significantly lower values than the control group at both time points (P<0.05). Conclusion: Abdominal electrical stimulation combined with airway clearance techniques can significantly improve pulmonary function, reduce inflammation, and enhance exercise tolerance and quality of life in patients with COPD. |
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