| 耿阿燕,眭有昕,朱仕哲,王庆雷,阚超杰,沈滢,王彤,郭川.预调控模式下非侵入性脑刺激技术的研究进展[J].中国康复,2026,41(8):495-500 |
| 预调控模式下非侵入性脑刺激技术的研究进展 |
| The research progress of non-invasive brain stimulation techniques in the priming paradigm |
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| DOI:10.3870/zgkf.2026.08.009 |
| 中文关键词: 非侵入性脑刺激技术 预调控模式 脑卒中 帕金森病 抑郁症 |
| 英文关键词: non-invasive brain stimulation priming paradigm stroke Parkinson’s disease depression |
| 基金项目:国家自然科学基金青年项目 (82302882) |
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| 中文摘要: |
|  预调控模式下非侵入性脑刺激技术(NIBS)是基于元可塑性机制的一种优化的神经调控方案,即在主要的NIBS干预前,预先应用另一种或相同形式的NIBS,以改变神经元活动水平并调节突触可塑性,从而影响后续主要的NIBS的效应。虽然该技术在临床应用中取得了一定成果,但其原理、机制和疗效仍存在不明确之处。本文旨在综述预调控模式下非侵入性脑刺激技术的研究进展,以期为拓展其临床应用提供参考依据。 |
| 英文摘要: |
| The priming paradigm of non-invasive brain stimulation (NIBS) represents an optimized neuromodulatory approach based on metaplasticity mechanisms. This paradigm involves the pre-application of a different or identical NIBS intervention to modulate neuronal activity and synaptic plasticity, thereby enhancing the effects of the main NIBS intervention. Although this paradigm has shown promising clinical potential, its underlying principles, mechanisms, and therapeutic efficacy remain unclear. This review aims to summarize the current research on the priming paradigm of NIBS, providing a reference for expanding its clinical applications. |
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