| 薛翠萍,陈可可,黄佩玲,张黎明,赵茹莲,方伯言.早中期帕金森病患者全维度注意功能特征及注意功能亚型分类研究[J].中国康复,2026,41(9):515-520 |
| 早中期帕金森病患者全维度注意功能特征及注意功能亚型分类研究 |
| Characteristics of full-dimensional attention function and classification of attention function subtypes in patients with early-to-mid-stage Parkinson’s disease |
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| DOI：10.3870/zgkf.2026.09.001 |
| 中文关键词: 帕金森病 注意功能 认知功能 分类 |
| 英文关键词: Parkinson’s disease attention to functionality cognitive function classification |
| 基金项目:国家重点研发计划（2022YFC3602603），首都医科大学附属北京康复医院引进人才科研启动基金（2023R-04） |
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| 中文摘要: |
| 目的：描述早中期帕金森病患者全维度注意功能变化特征、探索基于注意功能分型及对比分析各注意功能亚型认知、运动功能差异。方法：本研究为横断面研究，纳入112例早中期原发性帕金森病患者及性别、年龄、受教育年限匹配的30位正常人为研究对象。采用数字广度测试、连线测试、Stroop色词测试、听觉连续加法测试对被试进行各维度注意功能测试，并采用简易智力状态检查量表、蒙特利尔认知功能评定量表进行总体认知功能检查，采用国际运动障碍学会统一帕金森病评定量表第Ⅲ部分评估患者运动功能。分析早中期帕金森病患者各注意维度功能变化的特征，对患者注意功能进行探索性聚类分类，并分析各注意功能亚型总体认知及运动功能差异。结果：帕金森病认知障碍组41例，在各注意维度测试中均与帕金森病认知正常组、正常组有统计学差异(P<0.05)。帕金森病认知正常组71例，在连线测试错误数、Stroop耗时数干扰量成绩与正常组差异有统计学意义(P<0.05)。探索性聚类分析提示PD患者可能呈现高转移-高分配型、高维持-均衡型以及低转移-低选择型三种类型。低转移-低选择型的患者总体认知功能、运动功能显著低于其他亚型(P<0.05)。结论：早中期帕金森病患者会出现注意选择及转移功能下降，随着总体认知功能下降其他维度的注意功能也出现下降。研究观察到低转移-低选择型患者在总体认知、运动功能明显低于其他亚型，为未来临床工作中针对性评估及治疗提供初步依据和值得验证的假设。 |
| 英文摘要: |
| Objective: To describe the characteristics of full-dimensional attention function changes in patients with early-to-mid stage Parkinson’s disease (PD), explore classification based on attention function, and compare the differences in cognitive and motor functions among attention function subtypes. Methods: This was a cross-sectional study. A total of 112 patients with early-to-mid stage primary PD and 30 normal controls matched for sex, age, and years of education were enrolled. The digit span test, trail making test, stroop color-word test, and paced auditory serial addition test (PASAT) were used to assess each attention dimension. The mini-mental state examination and montreal cognitive assessment were used for global cognitive function, and the movement disorder society unified Parkinson’s disease rating scale part Ⅲ was used to evaluate motor function. We analyzed the characteristics of atte-ntion function changes in each dimension, performed exploratory cluster analysis to classify patients’ attention function, and compared the differences in global cognition and motor function among subtypes. Results: There were 41 patients in the PD with cognitive impairment group, who showed significant differences from the PD with normal cognition group and the normal control group in all attention dimension tests (P<0.05). In the 71 patients with PD and normal cognition, the errors in the trail making test and the interference amount of Stroop time consumption were significantly different from those of the normal control group (P<0.05). Exploratory cluster analysis suggested that PD patients might be classified into three types: high-transfer-high-allocation type, high-maintenance-balanced type, and low-transfer-low-selection type. Patients in the low-transfer-low-selection type had significantly lower global cognitive function and motor function than the other subtypes (P<0.05). Conclusion: Patients with early-to-mid stage PD show decline in attention selection and transfer functions, and other attention dimensions also decline as global cognitive function declines. The study observed that patients in the low-transfer-low-selection type had significantly lower global cognitive and motor functions than the other subtypes, providing preliminary evidence and a hypothesis worth testing for targeted assessment and treatment in future clinical work. |
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