| 范美琴,杨挺,黄杨华,刘登建,吴家敏,陈碧芳,徐利,冯燕鹏,何佳丽.经皮迷走神经电刺激治疗中枢神经系统疾病运动功能障碍的研究进展[J].中国康复,2026,41(9):551-556 |
| 经皮迷走神经电刺激治疗中枢神经系统疾病运动功能障碍的研究进展 |
| Research progress on the application of transcutaneous auricular vagus nerve stimulation in central nervous system disorders with motor dysfunction |
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| DOI：10.3870/zgkf.2026.09.007 |
| 中文关键词: 经皮迷走神经电刺激 中枢神经系统疾病 运动功能障碍 神经可塑性 脑卒中 帕金森病 脊髓损伤 |
| 英文关键词: transcutaneous auricular vagus nerve stimulation central nervous system diseases motor dysfunction stroke Parkinson’s disease spinal cord injury |
| 基金项目:国家重点研发计划（2022YFC3602603） |
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| 中文摘要: |
| 经皮迷走神经电刺激(taVNS)作为一种非侵入性神经调控技术，近年来在改善中枢神经系统(CNS)疾病引起的运动功能障碍方面表现出新兴潜力。其核心机制在于通过激活“外周-中枢”通路，精准调控运动皮层可塑性，重塑神经递质平衡，激活胆碱能抗炎通路，减轻神经炎症。本文综述taVNS调控中枢神经系统疾病运动功能障碍的最新研究进展，整合机制研究与临床证据，旨在为中枢神经系统疾病运动功能恢复提供新的思路和方法，促进taVNS临床应用发展。 |
| 英文摘要: |
| Transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive neuromodulation technique, has shown emerging potentiality in recent years for improving motor dysfunction caused by central nervous system (CNS) disorders. The core mechanism of taVNS treatment lies in activating the “peripheral-central” pathway to precisely regulate motor cortical plasticity, reshape neurotransmitter balance, and activate the cholinergic anti-inflammatory pathway to mitigate neuroinflammation. This article systematically reviews the latest research progress on taVNS for modulating motor dysfunction in CNS disorders, integrating mechanistic studies with clinical evidences. The aim of this article review is to provide novel insights and approaches for motor function recovery in CNS disorders and promote the clinical application of taVNS. |
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