| Clinical efficacy of acupuncture combined with press needling in the treatment of simple obesity in children (strong stomach and weak spleen pattern) and its influence on insulin resistance |
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| DOI：10.3870/zgkf.2026.06.002 |
| EN KeyWords: obesity children acupuncture press acupuncture |
| Fund Project:河南省中医药专项课题项目(2024ZY3090)；郑州市医学科研项目（ZZYK2024096） |
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| EN Abstract: |
| Objective: To evaluate the clinical efficacy of conventional acupuncture combined with press needle therapy in children with simple obesity (strong stomach and weak spleen pattern) and its impact on insulin resistance, and to preliminarily explore the potential mechanisms using bioinformatics analysis. Methods: A total of 98 children aged 6-16 years with simple obesity (strong stomach and weak spleen pattern) were randomly divided into a control group (receiving conventional acupuncture) and an observation group (receiving conventional acupuncture combined with press needle therapy). The treatment lasted for 12 weeks. Changes in body weight, body mass index (BMI), body fat percentage (BFP), waist circumference, fasting plasma glucose (FPG), fasting insulin (FINS), and homeostasis model assessment-insulin resistance (HOMA-IR) were compared before and after treatment between the two groups. Additionally, transcriptomic data from the GEO database (GSE9624, GSE100599) were analyzed to investigate obesity-related abnormal signaling pathways and the potential regulatory mechanisms of acupuncture. Results: A total of 11 cases dropped out. Ultimately, 45 cases in the observation group and 42 cases in the control group completed this trial. Both groups showed significant reductions in body weight, BMI, BFP, and waist circumference (all P<0.05), with the observation group demonstrating greater improvements in all indicators than the control group (all P<0.05). In terms of glucose metabolism, the decreases in FINS and HOMA-IR were significantly greater in the observation group than in the control group (P<0.01). Bioinformatics analysis revealed that the PI3K-Akt and insulin signaling pathways were inhibited, while the Fo-xO and endocrine resistance pathways were activated in the obese state. Electroacupuncture intervention enriched pathways related to glucose and lipid metabolism and regulated hypothalamic central signaling.Conclusion: Conventional acupuncture combined with press needle therapy can safely and effectively improve body composition and insulin resistance in children with simple obesity (strong stomach and weak spleen pattern), with superior efficacy compared to conventional acupuncture alone. The mechanism of this combined therapy may involve modulation of the central nervous system and reversal of insulin signaling pathway abnormalities in peripheral adipose tissue. |
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