| The impacts of vagus nerve stimulation on swallowing function and serum growth differentiation factor-15, C-reactive protein, and Visinin like protein-1 in patients with swallowing disorders after pontine infarction |
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| DOI：10.3870/zgkf.2026.06.006 |
| EN KeyWords: pontine infarction swallowing disorders vagus nerve stimulation swallowing function GDF-15 CRP VILIP-1 |
| Fund Project:邯郸市科学技术研究与发展计划（24422083035ZC） |
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| View Counts: 38 |
| PDF Download Counts: 18 |
| EN Abstract: |
| Objective: To explore the impacts of vagus nerve stimulation (VNS) on swallowing function and serum growth differentiation factor-15 (GDF-15), C-reactive protein (CRP), and Visinin like protein-1 (VILIP-1) in patients with swallowing disorders after pontine infarction. Methods: From June 2024 to June 2025, 80 patients with swallowing disorders after pontine infarction in our hospital were randomly assigned into an electrical stimulation group ［using neuromuscular electrical stimulation (NMES) on the basis of routine swallowing rehabilitation training, 40 cases］ and a magnetic stimulation group (using VNS on top of routine swallowing rehabilitation training, 40 cases). The swallowing function, serological indicators, surface electromyography, and quality of life were compared. Results: After therapy, the scores of the standard swallowing function assessment scale (SSA) decreased in both groups, and the score of the magnetic stimulation group was prominently lower (P<0.01). After therapy, GDF-15, CRP, and VILIP-1 all decreased in both groups, and the indicators were prominently lower in the magnetic stimulation group (P<0.01). After therapy, both groups showed an increase in maximum wave amplitude and a decrease in swallowing duration, with the magnetic stimulation group showing more prominent changes (P<0.01). After therapy, the swallowing-quality of life scale (SWAL-QOL) increased in both groups, and the magnetic stimulation group scored prominently higher (P<0.01, 0.05). Conclusion: VNS can effectively improve the swallowing function of patients with swallowing disorders after pontine infarction, reduce GDF-15, CRP, and VILIP-1, enhance pharyngeal surface muscle function, and improve quality of life. |
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