| Efficacy of transcutaneous auricular vagus nerve stimulation in the treatment of post-stroke fatigue |
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| DOI：10.3870/zgkf.2026.07.002 |
| EN KeyWords: transcutaneous auricular vagus nerve stimulation post-stroke fatigue clinical efficacy |
| Fund Project:陕西省重点研发计划项目（2024SF-YBXM-686）；西安市创新能力支撑计划-医学研究项目（23YXYJ0139） |
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| EN Abstract: |
| Objective: To investigate the efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) in the treatment of post-stroke fatigue. Methods: A total of 60 patients with post-stroke fatigue were enrolled and randomly assigned to either an experimental group or a control group, with 30 patients in each group. Both groups received basic treatment. The experimental group was treated with taVNS, while the control group received sham taVNS. The treatment was administered twice daily for 20 min each session, over a continuous period of 4 weeks. The fatigue severity scale (FSS), Pittsburgh sleep quality index (PSQI), stroke-specific quality of life scale (SS-QOL), and modified Barthel index (MBI) scores were observed before and after treatment in both groups. Additionally, serum levels of interleukin-1β (IL-1β) and IL-6 were measured. Results: After treatment, FSS and PSQI scores decreased in both groups compared to pre-treatment levels, with the experimental group showing significantly lower scores than the control group (P<0.05). SS-QOL and MBI scores increased in both groups compared to pre-treatment levels, with the experimental group demonstrating significantly higher scores than the control group (P<0.01). Serum levels of IL-1β and IL-6 decreased in both groups after treatment compared to pre-treatment levels, with the experimental group exhibiting significantly lower levels than the control group (P<0.01). In the experimental group, FSS scores were positively correlated with serum IL-1β and IL-6 levels (P<0.01). Conclusion: TaVNS can effectively alleviate fatigue, improve sleep quality, and enhance the quality of life in patients with post-stroke fatigue. The mechanism may be associated with the downregulation of serum IL-1β and IL-6 levels. |
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