Abstract
The research progress of non-invasive brain stimulation techniques in the priming paradigm
  
DOI：10.3870/zgkf.2026.08.009
EN KeyWords: non-invasive brain stimulation  priming paradigm  stroke  Parkinson’s disease  depression
Fund Project:国家自然科学基金青年项目 (82302882)
作者单位
耿阿燕 1.南京医科大学第一附属医院康复医学中心,南京210029；2.南京医科大学康复医学院 
眭有昕 3.香港理工大学康复治疗科学系 
朱仕哲 1.南京医科大学第一附属医院康复医学中心,南京210029；2.南京医科大学康复医学院 
王庆雷 1.南京医科大学第一附属医院康复医学中心,南京210029；2.南京医科大学康复医学院 
阚超杰 2.南京医科大学康复医学院；4.常州市德安医院康复医学中心 
沈滢 1.南京医科大学第一附属医院康复医学中心,南京210029；2.南京医科大学康复医学院 
王彤 1.南京医科大学第一附属医院康复医学中心,南京210029；2.南京医科大学康复医学院 
郭川 1.南京医科大学第一附属医院康复医学中心,南京210029；2.南京医科大学康复医学院 
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EN Abstract:
  The priming paradigm of non-invasive brain stimulation (NIBS) represents an optimized neuromodulatory approach based on metaplasticity mechanisms. This paradigm involves the pre-application of a different or identical NIBS intervention to modulate neuronal activity and synaptic plasticity, thereby enhancing the effects of the main NIBS intervention. Although this paradigm has shown promising clinical potential, its underlying principles, mechanisms, and therapeutic efficacy remain unclear. This review aims to summarize the current research on the priming paradigm of NIBS, providing a reference for expanding its clinical applications.
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